ea0016p27 | Adrenal | ECE2008
Kopprasch Steffi
, Ansurudeen Ishrath
, Graessler Juergen
, Bornstein Stefan R
, Pietzsch Jens
Objectives: Oxidative stress is of critical importance in the pathogenesis of endocrinopathies. Since cholesterol serves as a major source of steroid hormone synthesis we investigated the effect of hypochlorite-modified low density lipoprotein (LDL) on aldosterone and cortisol release from human adrenocortical NCI-H295R cells.Methods: Native LDL obtained from healthy volunteers was oxidized to varying degrees by sodium hypochlorite. The resulting modifie...